Wound healing, as a standard biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For an effective healing, all four phases must occur in the correct sequence and time frame. Many factors can interfere with one or more phases of this process causing impaired wound healing. The task of managing non-healing wounds especially in instances with bone exposure is clinically challenging, if not difficult. Platelet-rich fibrin (PRF) represents a new step in the platelet gel therapeutic concept with simplified processing minus artificial biochemical modification. This article aims to describe a case of bone exposure after subepithelial connective tissue grafting and its management with platelet rich fibrin.
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