Premature Centromere Division in Oral Premalignant and Malignant Patients - A Cytogenetic Biomarker
JBCAHS Vol 1 Issue 1 2017 Coverpage
Uma AN
Genetic Division, Department of Anatomy, Mahatma Gandhi Medical College and Research Institute, Pondicherry - 607402
Tirou Aroul T
Department of General Surgery,Mahatma Gandhi Medical College and Research Institute, Pondicherry - 607402
Dhananjay S Kotasthane
Apoorvalakshmi S
Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, 607 402
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Keywords

Tobacco chewers
clastogenic agents
oral premalignant disorders
oral squamous cell carcinoma
chromosomal alterations
genotoxic biomarker

How to Cite

1.
AN U, T TA, Kotasthane D, S A. Premature Centromere Division in Oral Premalignant and Malignant Patients - A Cytogenetic Biomarker. jbcahs [Internet]. 7Nov.2017 [cited 24Sep.2018];1(1):20 -25. Available from: https://www.jbcahs.org/journal/article/view/37

Abstract

Background and Objective:

Premature centromere division (PCD) is characterized by the distinct separation of chromosomes earlier than usual and this cytogenetic phenomenon has been reported to be associated with aneuploidy and cancer. In the present study, PCD test was used to find out whether it could be used an indicator for oral premalignancy and malignancy.

Material and Methods:

PCD test was thus used on 60 histopathologically confirmed oral premalignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) patients, using the standard Hungerford method, to find out if this cytogenetic parameter could be used as an indicator for oral disease.

Results:

The mean of PCD showed an increased chromosomal alteration from controls (5.63 ± 2.67) to OPMDs (23.47 ± 8.08) and further increased mean value in OSCC (29.47 ± 6.29) correlating well with the histopathological diagnosis of the oral disease.

Conclusion:

The results indicate that PCD can be considered a good and easily identifiable parameter which can be used as a genotoxic biomarker in chromosomal studies, facilitating early diagnosis of oral cancer.

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